Molecular im Yasni Exposé von Gunter Kraus

Infection with a particularly neurovirulent strain of HIV has been hypothesized to explain why only a subset of patients develops HIV encephalitis. We studied the third hypervariable region (V3) of multiple clones from both brains and spleens of three patients who died with HIV encephalitis, to see if there was a molecular signature associated with neurological disease.

The present invention relates to methods and means for the evaluation of HIV treatment. In particular, molecular events at the HIV gag and protease proteins and their effect on therapeutic efficacy of drugs are determined The methods rely on providing HIV gag and protease nucleic acid material and evaluating a

The Interdisciplinary Biomedical Studies (IBS) program provides an entry point ... the fundamentals of modern molecular and cellular biology. ...

We have previously described a hairpin ribozyme that targets a highly conserved sequence in the U5 region of HIV-1. To determine if escape mutations would compromise virus replication, we introduced critical mutations into the ribozyme target site of an infectious molecular clone of HIV-1MN.

SIVagm is a lentivirus closely related morphologically and genetically to HIV. 40% of African Green Monkeys (AGM) in the wild are found to be seropositive without any signs of disease.